What Is Crinone Progesterone Gel 8% Used For?

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what is crinone 8 gel used for

Progesterone is a hormone which stimulates and controls a number of functions such as, maintaining a pregnancy and regulating the monthly cycle. It is produced in the ovaries, the placenta (if a woman conceives) and the adrenal glands. After ovulation, the corpus luteum (it’s an empty follicle, which is left after the egg is released) releases progesterone, which acts on the uterus lining causing it to thicken in preparation for pregnancy. This phase is termed as the luteal phase of the monthly cycle. If fertilization and implantation occur, the corpus luteum continues with its role of progesterone production to sustain the pregnancy until the placenta has fully developed to take over progesterone production. However, if a woman has inadequate progesterone during the luteal phase, she may experience difficulties getting pregnant. Below are symptoms of low progesterone:

  • Headaches
  • Migraines
  • Low sex libido
  • Hot flashes
  • Irregular periods
  • Mood changes like anxiety and depression

A pregnancy may occur despite low progesterone levels; however, you are at a greater risk of experiencing a miscarriage since progesterone is vital to enable the uterus to carry the pregnancy to term. During pregnancy, the following are signs of inadequate progesterone:

  • Spotting
  • Abdominal pain
  • Constant breast tenderness
  • Frequent low blood glucose
  • Vaginal dryness
  • Constant fatigue

It’s important to visit a medical care provider if you detect any of the listed symptoms if trying to conceive or if pregnant. If the fertility expert establishes you have insufficient progesterone, he may prescribe Crinone 8% gel.


What is the Drug Used For?

Progesterone Crinone 8 % Gel

The medication contains progesterone as the active ingredient and it is used to treat progesterone deficiency. Additionally, it’s used in a woman who doesn’t menstruate and has been unresponsive to a lower strength of the Crinone gel. The gel comes in pre-filled applicators and it’s crucial to follow the physician instructions on how to use this medication. Normally, one applicator is inserted into the vagina daily or as directed by the doctor, starting a day after ovulation or between the 18th day to 20th day of the menstrual cycle. If pregnancy occurs, continue using the gel until the placenta is producing adequate progesterone to maintain the pregnancy; The drug  is used for at least the first 12 weeks after conception.


How to Insert


Some women find it uncomfortable inserting the medication into the vagina, however, if the doctor has prescribed the drug it is important to use it and help you with conception and maintaining a healthy pregnancy. The procedure on how to insert Crinone gel is easy. The pre-filled applicator has a thick and a thin end, hold the applicator on the thick end and shake down for the content to be on the thin end. Twist off the tab and insert the thin end gently inside the vagina while in a sitting position or lying on the back with the knees bent. Press the thick end of the applicator firmly for the gel to be deposited. Remove and throw the applicator; each applicator is used only once. The Crinone 8% progesterone gel coats the inside of the vagina providing prolonged release of the progesterone into your vaginal; it’s then drawn into the bloodstream.


Crinone and IVF


In vitro fertilization (IVF) is a technique that helps couples with fertility problems become parents. Eggs are removed from a female’s ovary and fertilized in a laboratory. The embryo which is the fertilized egg is transferred into a woman’s uterus to grow and develop. Progesterone supplementation is important for conception and staying pregnant after IVF, so, Crinone gel may be used. A woman going through IVF requires more progesterone since in vitro process isn’t natural; you take medicines to produce multiple follicles and to prevent premature ovulation. Once the follicles have matured, human chorionic gonadotropin is administered to trigger ovulation, the eggs are harvested when the body least expects it; the whole process disrupts the natural function of progesterone hormone, this is an explanation of the need for the Crinone to support implantation and avoid a miscarriage. The gel is considered very effective since it’s readily absorbed into the bloodstream. Ensure you follow the prescribed dose, the medication instructions and discard the applicator after use.


Side Effects


Whether using the medication in assisted reproductive cycle, such as in vitro fertilization or in a natural cycle, you may experience side effects such as:

  • Breast enlargement
  • Breast pain
  • Changes in sex drive
  • Constipation
  • Cramps
  • Diarrhea
  • Painful sexual intercourse
  • Drowsiness
  • Fatigue 
  • Fluid retention
  • Pain around the vaginal area
  • Urination at night
  • Severe allergic reaction
  • Dizziness 

Crinone gel unwanted effects affect people differently, hence you may encounter some unwanted effects or none at all. If they occur or need additional information, contact the physician. Don’t use the drug if allergic to it or if you have cancer of the breast, ovary, lining of the uterus, vagina or the cervix. Remember to inform the medical care provider of the existing medical condition and all the drugs you are taking as possible drug interaction may occur.




  1. If you are diabetic, this drug may make it difficult to regulate blood glucose levels. If you develop signs of elevated blood sugar levels like increased thirst and urination, monitor glucose levels regularly.
  2. Do not skip the doctor’s appointments, they are crucial for some tests to be carried out like Pap smear, breast, and pelvic exams, to check your condition or to detect undesirable effects
  3. The gel can result in dark patches on the face; use a sunscreen protection to prevent the patches from darkening.
  4. If using another medication which is applied vaginally, don’t use it at the same time with the gel, but administer it at least six hours after or before Crinone, unless the physician gives different instructions
  5. The effectiveness and safety of the medication hasn’t been established in children, so it shouldn’t be used on children
  6. Don’t engage in activity that requires you to be alert since the medication may cause dizziness. Until you are certain you can safely carry out the activities
  7. If breastfeeding, inform the doctor since the medicine passes into breast milk
  8. This medication is harmful if swallowed; contact an emergency room immediately, if accidentally taken by mouth


In Conclusion


You are enlightened on the importance of Crinone 8% gel and pregnancy. The drug has benefited many women dealing with infertility and prevented miscarriages, its advantages outweigh the potential risks in many females. The medication price is affordable and you can buy it online.

Article Name
What Is Crinone Progesterone Gel 8 % Used For?
Crinone 8 gel contains progesterone as the active ingredient and it is used to treat progesterone deficiency. Additionally, it’s used in a woman who doesn’t menstruate and has been unresponsive to a lower strength of the Crinone gel.
Publisher Name
Fertility Drugs Online
Publisher Logo

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