Crinone Uses And Its Side Effects

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crinone side effects

Progesterone is crucial in childbearing years. Inadequate progesterone makes it difficult to get pregnant or maintaining a pregnancy. Progesterone thickens uterus lining every month in preparation for fertilized egg implantation. In case a pregnancy takes place, production of progesterone takes place in the placenta. For the entire period of the pregnancy, progesterone levels remain elevated. You can now understand the importance of progesterone. If progesterone levels are low, the doctor prescribes Crinone gel either during fertility treatment or during pregnancy to successfully carry out the pregnancy to term. You are at a risk of side effects of Crinone.


What is Crinone?

Progesterone Crinone 8 % Gel

It is a vagina gel which contains progesterone. For the drug to be effective, it causes wanted and unwanted side effects. Crinone has two different strengths; 4 % gel and 8 % gel.


Uses in IVF & Pregnancy


Crinone is used during fertility treatment that is assisted reproductive technology (ART) for example,  in-vitro fertilization (IVF). Using this vaginal gel during IVF can make you prone to its side effects. If you are a healthy woman with normal progesterone levels, after ovulation, your follicle, which hosted the egg changes to corpus luteum for the production of progesterone. Progesterone prepares the lining of your uterus in readiness for the fertilized embryo. Remember, IVF is not natural. You use medication to produce several follicles and to stop your ovaries from releasing more eggs prior egg retrieval. The eggs are collected and fertilization takes place outside your body. After fertilization, the fertilized egg is put into your uterus. IVF interferes with the normal production and function of progesterone. Your body will require progesterone to prepare your body for the pregnancy; though you will be faced with side effects of the Crinone cream. Bear in mind, if the medications have not triggered ovulation, you may need to use donated eggs, you have no choice but to take the gel to make the uterus ready to carry the pregnancy. In the course of use, you will be faced with, side effects of Crinone gel. By the time the fertilized egg is placed back into your uterus, this medication will do the following:


  1. Stimulate blood vessels to grow; Blood vessels supply your uterus lining (endometrium) with blood.
  2. Assist the glands in the lining of the womb to produce nutrients to sustain the embryo.
  3. Support endometrium during pregnancy


The drug is useful if your inability to conceive is as a result of the deficiency of progesterone in your body. A sure sign of infertility is secondary amenorrhea and this gel treats the condition. Secondary amenorrhea is an absence of periods for at least six months or more; in secondary amenorrhea, you have your period once or more, then the period stops. Low progesterone is associated with the absence of periods. Therefore, Crinone causes your period to come back and you will also have to handle its side effects. Many miscarriages happen within the first trimester. Doctors believe this medicine lowers chances of women having a miscarriage; lack of progesterone can trigger miscarriage. Thus, this drug is highly advocated for during pregnancy. To support the pregnancy, you use this drug for the first 12 weeks of pregnancy. After that, your body through the placenta will produce enough progesterone until you deliver. But your doctor has the final say on this (when to stop progesterone).


How to Use


The drug must be prescribed by the doctor. The doctor will also guide you on how to use this medication.  You put the gel inside your vagina using a prefilled applicator. The gel covers your vagina; it will be released throughout the day and absorbed by your bloodstream.


Side Effects


The most common negative effects:


  • Bloating
  • Stomach pain and cramps
  • Nausea 
  • Headache
  • Dizziness
  • Drowsiness
  • Vomiting 
  • Feeling tired
  • Diarrhea 
  • Constipation
  • Pain in the vagina
  • Pain during sex
  • Breast swelling or tenderness
  • Join pain
  • Reduced interest in sex
  • Urinating frequently at night
  • Vaginal discharge
  • Vaginal burning 
  • Vaginal itching
  • Bleeding 


Before using this medicine, it is advisable to ask your doctor about the expected negative effects of this medication and how to deal with them. Having the information in advance will help you to be vigilant and know when to contact your healthcare provider. Crinone side effect bleeding can be scary and troublesome, but being aware of its occurrence as an undesirable effect will make you calm and prevent you from panic. Other less common but serious side effects of Crinone suppositories include:


  • Rash 
  • Jaundice
  • Difficulty speaking
  • Glucose intolerance
  • Ectopic pregnancy
  • Blood clots 
  • Vaginal candidiasis 
  • Depression 
  • Swelling or pain in the legs
  • Fever, chills and body aches
  • A lump in the breast
  • Chest pain


Contact your health care provider with immediate effect if you experience the above serious unwanted effects for the doctor to determine if you should stop the medication or continue taking it.


Precautions to Take


Every drug comes with a leaflet. Therefore, see to it that you read the leaflet as it contains beneficial information about this medicine. It does not mean you shouldn’t ask your doctor any questions; the leaflet contains an overview of Crinone and the ingredients/chemicals used to make it. Don’t destroy the leaflet, but keep it with Crinone, you may need to refer to it. Inform your doctor if you are allergic to the medication ingredients. The following are symptoms you can experience if you are allergic to the drug ingredients:


  • Rash on your skin
  • Swelling of the face, lips, tongue and other body parts 
  • Difficulty breathing


If you are allergic to this medication, you should avoid it but you have to inform the doctor on the allergy. Sorbic acid is one of the ingredients responsible for the drug side effects vaginal irritation. Use condom during sex to prevent a skin reaction on your spouse’s penis. Crinone has prefilled applicators which should be used once and discarded. Inform your physician if you have the following so that you can be closely monitored:


  • Asthma
  • Migraines 
  • Depression
  • Epilepsy
  • Diabetes
  • Heart disease
  • High blood pressure
  • Kidney and liver problems


You can’t use the drug if you have some medical conditions such as:


  • Vaginal bleeding which is abnormal and the cause is vague
  • Have breast cancer
  • Have a blood clot
  • You have ever experienced a heart attack or stroke
  • You have a stillbirth


In Conclusion


Follow the prescription of the doctor and get in contact with him in case the side effects, for example, if Crinone side effect cramps persist and interfere with normal routine. May Crinone be beneficial to you and live to share a success story.

Article Name
Crinone Uses And Its Side Effects
The doctor prescribes Crinone gel either during fertility treatment or during pregnancy to successfully carry out the pregnancy to term. You are at a risk of side effects of Crinone.
Publisher Name
Fertility Drugs Online
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