Cetrotide is an injection primarily used in assisted reproduction techniques such as IVF. It belongs to class of medications popularly known as GnRH antagonists. However, compared to other antagonists, Cetrotide is much newer and serves as a quick fix to premature ovulation. It’s also easy to use and features a high pregnancy rate. Read on for advice on Cetrotide protocol and possible side effects.
Before we jump into that, let us identify how this active agent actually works.
How does Cetrotide work?
Cetrotide injection contains an active ingredient known as cetrorelix- a synthetic hormone commonly referred to as (GnRH). It is this ingredient that blocks the effect of luteinising hormone (LH), an agent responsible for causing ovulation. By blocking the effect of LHRH, the injection prevents premature ovulation which normally results to release of eggs which are either premature or unsuitable for use in assisted reproduction treatment such as vitro fertilization technique (IVF).
The injection is usually used with the aid of follicle stimulating hormone (FSH). The two serve as active ingredients used in the treatment of infertility in women having assisted reproduction treatment.
It is important to note that administration of Cetrotide can only be done under the supervision of a specialist. The injection is administered under the skin, preferably in the lower abdomen.
Protocol for Using Cetrotide
Cetrorelix is available in disposable, pre-filled, ready to inject syringes containing 250 micrograms of Cetrotide. Mixing is not required. It can be self injected through the supplied syringe.
There are two protocols for beginning Cetrotide. The first Cetrotide protocol is known as the flexible start, it monitors the egg development through ultrasound. It also operates through examination of blood results. With flexible start, Cetrotide is administered once the egg development begins.
The second Cetrotide protocol is referred to as the fix start. It uses a technique that allows Cetrotide to be administered after a certain number of days, primarily after fertility medication. The drug is prescribed irregardless of blood results or ultrasound monitoring.
What are the risks associated with Cetrotide?
There are no severe side effects associated with Cetrotide. What has been reported is, mild to moderate overstimulation of the ovaries. There are also a few cases of injection reactions which include
- redness and itching
For more information on side effects of Cetritide, please see the package leaflet.
Note: Cetrotide is not recommended for pregnant or breastfeeding women. Patients with severe kidney disease are also advised to stay away from the drug.
The primary advantage of Cetrotide is that it does not have a “flare phase” also known as suppression. A number of experts have linked earlier IVF cycles to pituitary suppression-a major cause that prevents fertility medications to respond well. Whether this occurs or not is subject to debate. But what is evident is that, with the use of Cetrotide, there is no concern for this problem. What’s more is that, compared to other antagonists, Cetrotide shortens the number of days a woman has to take injections.
For more information on Cetrotide protocol and Cetrotide administration, please contact your nearest fertility specialist.