Your fertility can be affected by internal and external factors and some examples of these factors are:
- Poor diet
- Hormonal imbalance
- Conditions affecting ovulation
- Blocked fallopian tubes
- Elevated levels of prolactin hormone
- Conditions affecting the uterus
Some factors, such as medical issues are beyond your control, but others are. Lifestyle choices like the foods one eat have the capability of affecting your fertility positively or negatively; eating junk food can lead to obesity, hormonal imbalance and cause infertility. At times, hormonal imbalance is to blame for irregular periods and ovulation disorders. Fertility drugs such as Repronex help to treat issues that lead to infertility.
What is Repronex?
As earlier mentioned, it is a fertility medication and it is extracted from the urine of postmenopausal women who produce the hormone in higher levels. Shocked to learn it is extracted from urine? That’s the truth, but the good news is that the urine is purified to make the Repronex injections. The drug falls under the category of human menopausal gonadotropin (HMG) or Menotropin. Each vial of Repronex contains:
- 75 international units (IU) of (FSH) follicle stimulating hormone
- 75 international units (IU) (LH) of luteinizing hormone
- 20 mg lactose monohydrate
What is the Drug Used For?
The medication is a prescription drug used to treat infertility in both men and women. The drug stimulates the development of ovarian follicles and the dosages vary from one patient to another. Ideally, a patient should be given the minimal dose which will bring out the desired outcome. Depending on how the patient reacts to the drug, the dose can be adjusted once every two days. The increment is between 75 IU to 150 IU and the daily dosage shouldn’t exceed 450 IU; this means 450 IU is the maximum dose strictly taken for 12 days only.
The medication comes in the form of a powder and the dosage depends on an individual circumstance. The physician will show you how to mix the drug in readiness for the shot. The dose prepared is used immediately and unused material discarded. This infertility medication may be used in combination with other fertility drugs. The recommended starting dose for follicular growth is 150 IU and administered through an injection. Does the word injection make you nervous? If you leave near your doctor’s office, the doctor may give the shot. However, you may be trained to carry out the shots at home. The injection procedure is easy to understand, if, for some reasons you can’t self-administer the injection, your partner may be trained to give the shots; the crucial thing is to follow the medication instructions regardless of who gives the injection.
The injection is given into a muscle or under your skin once daily starting from the second or the third day of the monthly period for eight to 12 days. The fertility specialists will closely monitor the progress of the eggs and the follicles, through ultrasounds and blood tests to confirm they have matured and ready to be released. At this point, HCG injection will be given to induce ovulation, after the human chorionic gonadotropin, it is the perfect timing to try to get pregnant by having sexual intercourse daily if going through the natural cycle.
However, the HCG shot may be withheld if the ultrasound results indicate abnormally enlarged ovaries or if the patient experience abdominal pains. Another precaution is to abstain from sexual intercourse. The measures taken may lower chances of ovarian hyperstimulation syndrome and multiple pregnancies. Once everything has been put in control and the HCG injection is given, the medical practitioner monitors the woman closely for two weeks. If the follicle development is unsatisfactory or ovulation occurs, but conception isn’t attainable, Repronex treatment can be repeated up to a maximum of six cycles. If a woman has a primary ovarian failure, she shouldn’t use 75 IU for follicular growth and maturation.
Using in Assisted Reproductive Technologies
Before having a discussion on assisted reproductive technologies, let’s have a look at another brand name for HMG drug which is Menopur; remember Repronex is a brand name as well. There has always been a debate on Repronex vs Menopur. The two medications work in a similar manner as they are both extracted from the urine of postmenopausal women and contain equal portions of FSH and LH. The only difference is Repronex has been in the market earlier (it is an older drug) whereas, Menopur is the newer medicine, thus better purified and its reactions on the injection sites are minimal. The bottom line is they are chemically the same; none is superior to the other.
Infertility has never been easy to deal with since time in memorial, thanks to technology which has made couples become parents. There are several types of assisted reproductive technologies such as:
- In vitro fertilization (IVF)
- Gamete intrafallopian transfer (GIFT)
- Zygote intrafallopian transfer (ZIF)
- Intracytoplasmic sperm injection (ICSI)
- Donor eggs
- Intrauterine insemination (IUI)
For the purpose of this article, the focus is on Repronex and IUI as well as IVF. Women with PCOS and endometriosis has benefited from the use of Repronex during in vitro fertilization and intrauterine insemination. A patient with mild endometriosis responds better on IUI, but for a severe case, IVF is used. During in vitro fertilization, fertilization takes place outside a woman’s body whereas, in IUI, the sperms are placed inside the body of a female to help with conception. Repronex remedy works in the same way as elaborated in the 1st section during the ART’s. Although there is a slight difference in the dosage used, it is a bit higher since the success of IVF and IUI depends on the number of mature eggs released. The starting dosage is 225 IU, if not responsive to the dosage, it is increased gradually as previously explained, although the maximum dose still stands at 450 UI for a maximum of 12 days only.
Menopur and Repronex contain a mixture of FSH and LH, the follicle stimulating hormone portion aids the follicle to produce a number of viable eggs. The luteinizing hormone portion, on the other hand, triggers the ovaries to lease estrogen to support your follicles in the production of eggs used in IUI and IVF. Additionally, the LH prepares the uterine lining in readiness for implantation. Once the eggs have reached maturity, HCG shot is given and the procedure for IUI and IVF are scheduled to take place, of course, depending on the ART the doctor has recommended. Normally, women firs use IUI and if conception fails IVF is used as the alternative.
Success Rates in Pregnancy
The success rate is almost 80 percent in women who ovulate within the first three cycles; at least 60 percent of the patients will conceive this is a great deal of success. But bear in mind some pregnancies won’t be carried to term; miscarriages and ectopic pregnancy are partly to blame.
Every drug has a dark side of negative effects, rarely talked about. Before the fertility expert puts you on the medication, it’s important to have a discussion on the Repronex side effects and the actions to take if they occur. Most patients on this drug experience mild or no unfavorable effects. Below are the side effects which may be mild, common or severe:
- Pain, swelling, redness on the injection spot
- Stomach cramps
- Allergic reactions
- Breast pain
- Enlarged breast
- Abnormal vaginal bleeding
- Ovarian hyperstimulation syndrome
You may encounter other side effects which are not included in the above list, feel free to contact the doctor. The side effects clear on their own, however, if they become intolerable and interfere with the daily activities, seek medical intervention.
Dealing with infertility calls for financial commitment and one must be prepared. The drug price is a bit high and may be expensive if the woman has to go through a series of cycles. Repronex cost doesn’t include costs such as IUI or IVF and most insurance doesn’t cover the fertility medication because infertility is viewed as an elective procedure. If you have an insurance plan, get to know what it covers and if one can find a better insurance to lessen the burden the better. Ask the fertility specialist on Repronex cost before starting fertility treatment to be prepared financially; you wouldn’t want a situation of starting the medication and once your body responds as expected you have to stop the medication because of cash shortages. Such a circumstance is discouraging and nerve wracking and may lead to stress. Once the doctor prescribes the medication, a patient can buy this drug online from a reputable fertility pharmacy.
Stick to the dosage prescribed and take the shots on the injection spots shown. Be on the lookout of the negative effects. Nonetheless, don’t concentrate on the negative side of the medication, but look at the bright side of what the drug can do for you. The dream of becoming a parent will become a reality. Plan the budget of fertility treatment even before starting it to avoid disappointments and embarrassments.